Characters from various games released by Falcom (e.g. Dragon Slayer, The Legend of Heroes, and Ys series) come together in a school.

Okama is a man who has some problems. First off, his name means 'gay' in Japanese. Next, he has the hots for himself dressed as a girl. Finally, he ends up working at a transvestite bar where he has befriended a girl named Miki. This is not an easy matter to solve, because she only knows him as his female counterpart named Catherine. So how is a guy dressed as a girl supposed to come out to a girl as a heterosexual male? To make matters worse, she has a boyfriend who is trying everything in the book to get with her. Enter the exciting world of Okama Hakusho where love comes in many different flavors!

16-year old Keisuke Saji loves to fantasize about young beautiful women. He hopes to land the object of his affection, Koizumi Akira. However, Koizumi hates Saji (as well as all men) to the point of assault. While most guys take Koizumi's cold shoulder as a hint, Saji pursues head-on without having rejection faze him.

When "ordinary boy" Kagami Kazuya meets the beautiful tsukumogami Kiriha, his life gets turned upside-down. As a "Taboo Child" who draws the supernatural towards him, he receives orders from the God of the Land, Kukuri, to become an exorcist and defeat these evil forces. And so, he and Kiriha do battle. To find out information on these supernatural beings, Kazuya and his friends set up a counselor's club at school. But behind the typical-seeming troubles he hears about, he uncovers a major plot to target Kukuri... In addition to the sadistic-yet-beautiful tsukumogami Kiriha, the situation draws other girls to Kazuya to join the fray!