Luo Xiaohei is a young monster who normally takes the form of a small black cat. Living freely in the forests, gradual deforestation and human development force him to flee and find a new home. Wandering the city streets, the black cat struggles to survive until he encounters Feng Xi, a fellow monster who takes Xiaohei to an isolated island inhabited by a small group of monsters. Excited to find what he thinks is his new home, Xiaohei lives with the monsters for only a short time before Wuxian, a human Guild Executor, arrives on the island in pursuit of Feng Xi. Feng Xi and his companions manage to teleport off the island, leaving Xiaohei and Wuxian alone. Though Xiaohei refuses to cooperate with the man who attacked his friends, Wuxian forces the black cat to travel to the Guild along with him. Embarking on an uncertain journey, Xiaohei is exposed to a new perspective on the relations between humans and monsters in a rapidly changing world.

In the peaceful little town of Sakuranomori, a group of young friends are about to bid farewell to one of their own. Due to his parents’ business plans, Sana Hidaka has to move away from his quiet childhood home to the boisterous city of Tokyo. Though it pains him, he must say goodbye to his precious friends—the kind-hearted Aoi Oribe, the spunky Wakatsuki twins, Shuri and Shuusuke, and the cheerful and upbeat Nanaka Yatsushiro. But even though he is reluctant to leave them behind, he believes that no matter how far apart they are, they will always cherish the memories of their friendship. Five years later, Sana, now a 16-year-old high school student, returns to his hometown with the hope of restoring his old life. However, he quickly realizes that although his town may not have changed drastically, the friends he left behind are not who they used to be. Unsettling shadows loom over Sakuranomori as his friends hold new secrets and bear burdens that threaten the bonds they once shared.

It is the year 2100, and on the colonized Moon, a project is under way to explore new aspects of energy. Amami Kurau is the daughter of the chief scientist on the project, and on her 12th birthday, she accompanies her father to the lab to observe the experiments. Then something goes awry, and Kurau is struck by twin bolts of light. In the aftermath, her father is dismayed to find that his daughter is no longer his daughter. Rather, her body is now home to two energy entities with fantastic powers.

Three years since the return of the legendary Space Battleship Yamato, Earth has begun rebuilding itself and has made peace with the Gamilans. However, this recovery comes at the cost of utilizing the forbidden Wave Motion technology. Meanwhile, the notorious former crew members of the Yamato, who have each gone their separate ways, receive a psychic message from the mysterious Goddess Teresa. She urges them to return to their beloved ship and travel to the distant planet Terezart. They are promised a revolutionary power to combat the unprecedented threat of the relentless Gatlantis Empire, who are approaching Earth with all but innocent intentions. Unable to resist her plea, the crew reassembles and sets sail on another perilous intergalactic voyage, one that will test their sheer courage and versatility in the face of an even greater foe.