The year is 1999. Morioh, a normally quiet and peaceful town, has recently become a hotbed of strange activity. Joutarou Kuujou, now a marine biologist, heads to the mysterious town to meet Jousuke Higashikata. While the two may seem like strangers at first, Jousuke is actually the illegitimate child of Joutarou's grandfather, Joseph Joestar. When they meet, Joutarou realizes that he may have more in common with Jousuke than just a blood relation. Along with the mild-mannered Kouichi Hirose and the boisterous Okuyasu Nijimura, the group dedicates themselves to investigating recent disappearances and other suspicious occurrences within Morioh. Aided by the power of Stands, the four men will encounter danger at every street corner, as it is up to them to unravel the town's secrets, before another occurs.

Joutarou Kuujou and his allies have finally made it to Egypt, where the immortal Dio awaits. Upon their arrival, the group gains a new comrade: Iggy, a mutt who wields the Stand "The Fool." It's not all good news however, as standing in their path is a new group of Stand users who serve Dio, each with a Stand representative of an ancient Egyptian god. As their final battle approaches, it is a race against time to break Joutarou's mother free from her curse and end Dio's reign of terror over the Joestar family once and for all.

Years after an ancient evil was salvaged from the depths of the sea, Joutarou Kuujou sits peacefully within a Japanese jail cell. He's committed no crime yet demands he not be released, believing he's been possessed by an evil spirit capable of harming those around him. Concerned for her son, Holly Kuujou asks her father, Joseph Joestar, to convince Joutarou to leave the prison. Joseph informs his grandson that the "evil spirit" is in fact something called a "Stand," the physical manifestation of one's fighting spirit which can adopt a variety of deadly forms. After a fiery brawl with Joseph's friend Mohammed Avdol, Joutarou is forced out of his cell and begins learning how to control the power of his Stand. However, when a Stand awakens within Holly and threatens to consume her in 50 days, Joutarou, his grandfather, and their allies must seek out and destroy the immortal vampire responsible for her condition. They must travel halfway across the world to Cairo, Egypt and along the way, do battle with ferocious Stand users set on thwarting them. If Joutarou and his allies fail in their mission, humanity is destined for a grim fate.

In 1868, Dario Brando saves the life of an English nobleman, George Joestar. By taking in Dario's son Dio when the boy becomes fatherless, George hopes to repay the debt he owes to his savior. However Dio, unsatisfied with his station in life, aspires to seize the Joestar house for his own. Wielding an Aztec stone mask with supernatural properties, he sets out to destroy George and his son, Jonathan "JoJo" Joestar, and triggers a chain of events that will continue to echo through the years to come. Half a century later, in New York City, Jonathan's grandson Joseph Joestar discovers the legacy his grandfather left for him. When an archeological dig unearths the truth behind the stone mask, he realizes that he is the only one who can defeat the Pillar Men, mystical beings of immeasurable power who inadvertently began everything. Adapted from the first two arcs of Hirohiko Araki's outlandish manga series, JoJo no Kimyou na Bouken follows the many thrilling expeditions of JoJo and his descendants. Whether it's facing off with the evil Dio, or combatting the sinister Pillar Men, there's always plenty of bizarre adventures in store.