Thousands of years into the future, mankind has colonized other planets across the galaxy and completely forgotten about Earth. On one part of the galaxy, the female space pirates and their colossal starship Sol Bianca get a surprise when a young girl named Mayo stows away on board the ship. The crew then embarks on a journey to Earth to find the whereabouts of Mayo's parents and discover the secrets of the lost planet.

Five female pirates pilot the Sol Bianca, a starship with a higher level of technology than any other known. With it, they seek out riches, such as the Gnosis, an legendary item of power, and pasha, the most valuable mineral in the galaxy. Along the way, they must consider a stowaway's quest to save the one he loves, and seek revenge against those that have wronged them.

Tanis, a child genius, is the youngest son of two mad scientists. His family has spent their lives withdrawn from normal society living on an isolated island, where the couple conducts experiments on Tanis' siblings that result in them gaining abnormal abilities. However, this activity is put to a stop when they are caught and arrested. Tanis is brought by government officials to a more populated island, alongside his four siblings: Snow, a dog-human hybrid; Ashise, a plant-human hybrid; Aisley, a spider-human hybrid; and Suishi, a mind-reader. Being the only one who has not been genetically modified, Tanis takes on the responsibility of adapting his siblings to society, all while trying to conceal their' distinctive characteristics. [Written by MAL Rewrite]

A long time ago, Zeus, the great god, created a three–tier hierarchy of angels, top, middle and lower, although they were supposed to be equal. Also, Zeus appointed 6 angels as Saint Beasts who govern the animals of Earth. They were: Go, the seiyu; Shin, the genbu; Rei, the suzaku; Guy, the byakko; Yuda, the kirin; and Ruka, the hooh. However, Kira, the shooting star, and Maya, the fuga, didn’t attend the selection tests and left for the Earth. The six angels fulfilled their tasks faithfully. However, because of Zeus’s increasingly tyrannical acts, they begin to mistrust him. (Source: AnimeNfo)