Mushoku Tensei: Jobless Reincarnation Season 2 - Episode 0 After the mysterious mana calamity, Rudeus Greyrat and his fierce student Eris Boreas Greyrat are teleported to the Demon Continent. There, they team up with their newfound companion Ruijerd Supardia—the former leader of the Superd's Warrior group—to form "Dead End," a successful adventurer party. Making a name for themselves, the trio journeys across the continent to make their way back home to Fittoa. Following the advice he received from the faceless god Hitogami, Rudeus saves Kishirika Kishirisu, the Great Emperor of the Demon World, who rewards him by granting him a strange power. Now, as Rudeus masters the powerful ability that offers a number of new opportunities, it might prove to be more than what he bargained for when unexpected dangers threaten to hinder their travels.

In Edo period Japan (1603 to 1868), a strange new disease called the Redface Pox has begun to prey on the country's men. Within eighty years of the first outbreak, the male population has fallen to a quarter of the total female population. Women have taken on all the roles traditionally granted to men, even that of the Shogun. The men, precious providers of life, are carefully protected and the most beautiful of the men are sent to serve in the Shogun's Inner Chambers.

In the anime, Kuromi is traveling the world, searching for her missing older sister Romina. Throughout her journey, she gains companions, but also brushes up against evil organizations.

Kaede Komura is in love. After being seated next to the airheaded Ai Mie for the past three days, Komura cannot help but be attracted to his bespectacled classmate. Although he has yet to have a proper conversation with Mie, Komura dreams of the day when she will look his way. One day, Komura notices that his seatmate is not wearing her glasses, learning by questioning Mie that she forgot them and has a tendency of doing so. When he sees her struggle, a concerned Komura takes it upon himself to help his crush. As the boy offers his assistance to Mie day by day, her reasons for constantly losing her glasses slowly evolve from the answer she initially gave.