The action returns in this brand-new sequel to SHAMAN KING! Hana Asakura finds that being the son of Yoh & Anna Asakura isn't all it's cracked up to be, and his boredom has him itching for any kind of excitement. But when a fight comes straight to his doorstep, it's from a place he least expects—his own family? The battle for Asakura supremacy begins!

In her first life, the renowned and genius surgeon Dr. Aoi Takamoto was Elise de Clorance, a villainess of noble descent. Elise's selfishness, insolence, and obsessive love for her fiancé—Prince Linden de Romanoff—led to the deaths of her family members and, eventually, herself. Only after being reborn did Elise realize the error of her ways and decide that, instead of ruining lives, she would devote herself to saving them. But a tragic airplane crash robs her of her dreams too soon. By a miracle, Elise wakes up in her original body before her official engagement to Linden. Recognizing the chance to cherish her loving family and free Linden from an unwanted marriage, Elise wishes to use her advanced medical knowledge to continue down the path of saving lives. In a deal with the emperor, Elise is given only six months to prove that her true place is not on the throne, but rather with the wounded and ailing who desperately need her help.

After discovering that his orphanage was on the brink of closing due to financial stress, Finn, who was living freely on the streets, set out for a casino with the aim of making a fortune. However, nothing could have prepared Finn for the nightmare that was awaiting him. Once there, Finn encountered a car chase and bloody shootout caused by a man's “lucky” card. Finn will eventually learn what the shootout was about. The world order can be controlled by a set of 52 X-Playing cards with the power to bestow different superhuman powers and abilities to the ones that possess them. With these cards, people can access the hidden power of the “buddy” that can be found within themselves. There is a secret group of players called High Card, who have been directly ordered by the king of Fourland to collect the cards that have been scattered throughout the kingdom, while moonlighting as employees of the luxury car maker Pinochle. Scouted to become the group's fifth member, Finn soon joins the players on a dangerous mission to find these cards. However, Who's Who, the rival car maker obsessed with defeating Pinochle, and the Klondikes, the infamous Mafia family, stand in the way of the gang. A frenzied battle amongst these card obsessed players, fueled by justice, desire, and revenge, is about to begin!

In a world where the Demon King has died, a host of demigods capable of felling him have inherited the world. A master fencer who can figure out how to take out their opponents with a single glance; a lancer so swift they can break the sound barrier; a wyvern rogue who fights with three legendary weapons at once; an all-powerful wizard who can speak thoughts into being; an angelic assassin who deals instant death. Eager to attain the title of "True Hero," these champions each pursue challenges against formidable foes and spark conflicts among themselves. The battle to determine the mightiest of the mighty begins.