A direct continuation of the former season, this series again follows the story of Nozomi Yumehara and her friends from Yes! Precure 5. The girls who had formerly lost their powers and bade farewell to their friends Coco and Nuts from Palmier Kingdom are resurrected as Pretty Cure by the mysterious woman Flora who also wants them to find her in a place called Cure Rosegarden. To go there, they need the magic Rose Pact and the powers of the four kings of countries surrounding Palmier. But a dark organization called Eternal is also striving to get to Cure Rosegarden by stealing the Rose Pact. Luckily, Precure get helped by new allies: the delivery-boy Syrup who can change into a giant bird and fly them anywhere they want and the mysterious and beautiful fighter Milky Rose stand alongside Pretty Cure to protect what is really valuable.

Set in a different series of events, this story does not follow the previous Appleseed movie canon (despite being directed by the same director of the previous movies); it is an alternate story to their beginnings. Briareos is already a cyborg and did not become separated from Deunan to be later reunited in Olympus to join ESWAT.

Appleseed Alpha depicts the early days of Deunan Knute and Briareos in the 22nd century, as they embark on a journey throughout dystopic ruins of New York in search of the city of Olympus. They are hired by Two Horns, the warlord of the ruined city, to eliminate bipedal combat machines. During the fight, they encounter Iris and Olson, both on a mission. Deunan and Briareos befriend them and decide to join their mission.

Iris is tasked with preventing the malevolent cyborg Talos from capturing a secret weapon humans were building. Talos uses Iris to activate the gigantic war machine.

(Source: Wikipedia)

Tokiko Mima, nicknamed "Key," is a 17-year-old girl living in the Japanese countryside who, despite her human-like appearance, is a robot. When Key's grandfather Dr. Murao Mima passes away, he leaves her a dying message, telling her that she can become a real girl if she is able to make thirty thousand friends. Thus, Key moves from the quiet Mamio Valley to the busy streets of Tokyo, where she soon runs into her childhood friend Sakura Kuriyagawa. Key quickly becomes enamored with idol singer Miho Utsuse and wonders if becoming a singer will allow her to make the amount of friends needed for her to become human. But Miho carries a ominous secret: she is connected to Jinsaku Ajou, an old rival of Dr. Mima trying to make new a breakthrough in robotic weaponry. As Key works to become a real girl, Ajou sets a dangerous plan into action, and it turns out there's much more to Key than meets the eye. [Written by MAL Rewrite]

The official website for the Nanbaka television anime announced that the "Nanfes" event in April will screen a previously unreleased anime special.