World-class medical researcher Kanji Yakutani lost his little sister to a tumor years ago due to ineffective treatment. To honor her legacy, he has dedicated his research to developing new medications for such conditions. But as fate would have it, he overworks himself and passes away at the age of 31, only to be given a second chance at life in another world. When he wakes up, Kanji finds himself in the body of a 10-year-old boy named Falma de Médicis, the son of an esteemed family of medical practitioners in the Sain Fleuve Empire. Bearing the mark of a deity's divine blessing, Falma is capable of performing a unique divine art, allowing him to create and reduce any substance with the knowledge of its chemical properties. After reading through some pharmacology books, Falma realizes that this world is operating on similar medical practices as in ancient times. He also learns that medicine is an exclusive privilege to the nobility, depriving commoners of proper medical care. Using the knowledge from his past life and the divine abilities granted to him, Falma resolves to make medicine available to those who need it—irrespective of class.

Hiyori Hayama is an aspiring singer who moved to Tokyo to make her debut. She has always loved singing and hopes to stand on stage like her favorite artist. Unfortunately, the entertainment industry is not all fun and games, as she fails her auditions one after another and struggles to sell her songs. Finding herself still standing at the start line, Hiyori pursues her only opportunity to take the next step forward—partaking in Extreme Hearts. The popular event is a Hyper Sports tournament where participants compete in various sports using ability-enhancing gear for a chance to make their big break. Despite being athletic, however, Hiyori's lack of familiarity with Hyper Sports poses a problem for her. Fortunately, she befriends girls experienced in different sports, and they join the tournament alongside Hiyori, hoping to see her rise to the top. Now playing under Team RISE, Hiyori and her teammates learn about the unspoken rule of Extreme Hearts—all competitors must be entertainers or aspire to be one. For the members of Team RISE, facing the competition head-on is an inspiring endeavor that paves the way to discovering newfound interests and everlasting friendships.

Veyron City—a mega-floating metropolis created from the discovery of new energy sources. Shuu, a young man who owns and operates a small business in the area, leads a meager life due to his reckless spending. Kisara, a girl who visits Shuu's office and home because she is constantly concerned about him. She works while attending high school in Veyron City, doing everything from clerical work to housework. Ayano, Shuu's ex-girlfriend and a senior colleague at the corporation he had previously worked for, is also worried about him. Thus begins the slapstick romantic comedy of three people in a slightly unusual relationship that takes place on an artificial island in the Pacific Ocean.

The number of terrorist acts in Japan has never been lower, thanks to the efforts of a syndicate called Direct Attack (DA). The organization raises orphaned girls as killers to carry out assassinations under their "Lycoris" program. Takina Inoue is an exceptional Lycoris with a strong sense of purpose and a penchant for perfection. Unfortunately, a hostage situation tests her patience, and the resulting act of insubordination leads to her transfer out of DA. Not thrilled about losing the only place she belonged to, she reluctantly arrives at her new base of operations—LycoReco, a cafe in disguise. Takina's new partner, however, turns out to be quite different from what she imagined. Despite being the famed Lycoris prodigy, Chisato Nishikigi appears almost unconcerned with her duties. She drags Takina along on all kinds of odd jobs under the simple explanation of helping people in need. Takina is even more puzzled when Chisato takes down a group of armed assailants without killing any of them. Feeling like a fish out of water, Takina itches to get reinstated into DA—but Chisato is determined to prove to her that there is more to a life than just taking them.