Yoichi Isagi was mere moments away from scoring a goal that would have sent his high school soccer team to the nationals, but a split-second decision to pass the ball to his teammate cost him that reality. Bitter, confused, and disappointed, Isagi wonders if the outcome would have been different had he not made the pass. When the young striker returns home, an invitation from the Japan Football Union awaits him. Through an arbitrary and biased decision-making process, Isagi is one of three hundred U-18 strikers selected for a controversial project named Blue Lock. The project's ultimate goal is to turn one of the selected players into the star striker for the Japanese national team. To find the best participant, each diamond in the rough must compete against others through a series of solo and team competitions to rise to the top. Putting aside his ethical objections to the project, Isagi feels compelled to fight his way to the top, even if it means ruthlessly crushing the dreams of 299 aspiring young strikers.

On the planet Noman's Land, reporters Meryl Stryfe and Roberto De Niro traverse the desert in search of the infamous outlaw Vash the Stampede. But the man they find near the desolate town of Jeneora Rock is a far cry from the lethal terrorist they expect. In reality, Vash is a passive and carefree drifter; he is a proponent of peace, beloved by the residents of the town. His inaccurate reputation actually stems from the widespread atrocities committed by his twin brother Knives Millions. Still, Vash is dubbed "The Humanoid Typhoon'' due to the tendency for violent chaos to follow in his wake. Chaos soon arrives in the form of bounty hunters seeking the high price on Vash's head, and their violent pursuit poses great danger to the town and its precious power plant. Thanks to his gunslinging prowess, Vash is able to resist most of these nefarious forces. Yet he must soon face off against the ultimate evil: the unstoppable destructive power of his malevolent brother.

Mahiru Shiina is worthy of her nickname "Angel": she is a divine beauty loved by all, and she excels in both academics and athletics. Shiina lives in an entirely different world from Amane Fujimiya, her next-door neighbor. Despite living so close together, they have never spoken once. But their silence is broken when Fujimiya spots Shiina gloomily sitting on a swing amidst a heavy rainstorm and lends her his umbrella. When Fujimiya catches a cold the next day, Shiina wishes to return the favor for the umbrella by nursing him back to health. Believing that this would be their first and last interaction, he silently appreciates her kindness. However, Shiina—who can not help but worry about Fujimiya's lack of tidiness and proper nutrition—begins to cook and clean for him. As the unlikely pair spend time together in Fujimiya's apartment, they explore the true nature of their relationship and the gentle emotions that emerge from it.

For more than 30 years, Dariel has been a loyal soldier in the Demon King's army, having been raised by Granverza, one of the Four Heavenly Generals. However, as Dariel lacks any magical potential, he is nothing but a disgrace in the eyes of Granverza's son, Bashubaza, who fires Dariel right after assuming his father's position as a general. Stripped of a home and a job, Dariel wanders the forests, where he stumbles upon a human girl named Marika running from a monster. After Dariel intervenes to help Marika, she invites him to stay at her village in return. There, he discovers that the reason he has zero suitability for magic as a demon is that he is, in fact, a human. However, Dariel is no ordinary human. Possessing potential that far outweighs even heroes, Dariel may soon find himself involved in the humans and demons' seemingly never-ending conflict, facing against the race he once considered allies.