Dr. Kenzou Tenma, an elite neurosurgeon recently engaged to his hospital director's daughter, is well on his way to ascending the hospital hierarchy. That is until one night, a seemingly small event changes Dr. Tenma's life forever. While preparing to perform surgery on someone, he gets a call from the hospital director telling him to switch patients and instead perform life-saving brain surgery on a famous performer. His fellow doctors, fiancée, and the hospital director applaud his accomplishment; but because of the switch, a poor immigrant worker is dead, causing Dr. Tenma to have a crisis of conscience. So when a similar situation arises, Dr. Tenma stands his ground and chooses to perform surgery on the young boy Johan Liebert instead of the town's mayor. Unfortunately, this choice leads to serious ramifications for Dr. Tenma—losing his social standing being one of them. However, with the mysterious death of the director and two other doctors, Dr. Tenma's position is restored. With no evidence to convict him, he is released and goes on to attain the position of hospital director. Nine years later when Dr. Tenma saves the life of a criminal, his past comes back to haunt him—once again, he comes face to face with the monster he operated on. He must now embark on a quest of pursuit to make amends for the havoc spread by the one he saved. [Written by MAL Rewrite]

In times of need, if you look in the right place, you just may see a strange telephone number scrawled in red. If you call this number, you will hear a young man introduce himself as the Yato God. Yato is a minor deity and a self-proclaimed "Delivery God," who dreams of having millions of worshippers. Without a single shrine dedicated to his name, however, his goals are far from being realized. He spends his days doing odd jobs for five yen apiece, until his weapon partner becomes fed up with her useless master and deserts him. Just as things seem to be looking grim for the god, his fortune changes when a middle school girl, Hiyori Iki, supposedly saves Yato from a car accident, taking the hit for him. Remarkably, she survives, but the event has caused her soul to become loose and hence able to leave her body. Hiyori demands that Yato return her to normal, but upon learning that he needs a new partner to do so, reluctantly agrees to help him find one. And with Hiyori's help, Yato's luck may finally be turning around. [Written by MAL Rewrite]

Keitaro Urashima promised a girl when he was young that they would meet up again at Tokyo University in the future. Sadly, in the National Practice Exam, Keitaro ranked 27th from the bottom. Knowing his grandmother owned a hotel, Keitaro intended to stay there while continuing his studies for Tokyo U, only to find out the hotel had long been transformed into an all-girls dormitory. Through an odd twist of fate, Keitaro eventually became the manager of the dorm, beginning his life of living with five other girls.

Keitaro has finally passed the entrance exams, and is officially a Toudai student. But after breaking his leg in an accident in the entrance ceremony, he thought and re-evaluated himself. Having new goals, Keitaro follows Seta on an overseas archeology trip. During his absence, however, all was not well in Hinata Lodge. Urashima Kanako, Keitaro's sister, arrives on the scene. She claims to be the new manager of Hinata Lodge starts to go against all the tenants. Things become even more complicated when they recieve a letter from Keitaro. The tenants and Kanako made a big mess trying to get the letter, but Seta's car crashes in before anyone could read the letter...