In the town of Clock Hill, there is an old boarding house called Maison Ikkoku. While the residence itself is fairly normal, most of its occupants are not. Yuusaku Godai, its most quiet tenant, has finally reached his limit with his neighbors' constant disruptions and boisterous partying. Wanting a calmer place to call home so that he can study in peace, he prepares to move away. However, his plans to leave are suddenly interrupted when he meets the new boarding house manager, Kyoko Otonashi. Falling madly in love with her, he decides that the boarding house may not be such a bad place to live after all. Unfortunately for him, Kyoko has her own romantic troubles: she is a widow whose husband died six months into their marriage. And despite her blossoming feelings for Godai, Kyoko still cherishes her dearly departed husband, and she believes that no other man could possibly fill the void in her heart. But with Godai's persistence and some help of the other eccentric tenants, she may experience true love once again. [Written by MAL Rewrite]

Yui Komori, still held captive by the Sakamaki brothers—pureblood vampires after her blood—experiences yet more bizarre twists to her life following her stay at their household. Though haunted by enigmatic dreams, Yui soon deciphers their meaning when caught in a car crash, which subsequently leads to meeting four new vampires: the Mukami brothers, Ruki, Azusa, Kou, and Yuuma, who themselves capture the bewildered girl. Yui later awakens in the Mukami mansion, where the brothers reveal their plans for her: she is their "Eve," and her blood will find the "Adam" among them; together, they will have the power to rule the world. However, with the Sakamaki brothers hot on their heels, things might not go quite as smoothly as they had imagined.

At the behest of her father, Yui Komori goes to live in a secluded mansion, home to the six Sakamaki brothers—Shuu, Reiji, Ayato, Kanato, Laito, and Subaru—a family of vampires. Though at first the siblings are confused as to why the girl has arrived, they soon realize that she is to be their new "sacrificial bride," not to mention their other, more carnal intentions for her. After meeting the brothers, Yui quickly begins to question why her father would have sent her here and why she feels a strange, new pain in her chest. With each brother more sadistic than the last, Yui's life as a captive takes a harrowing turn in her new home. As her days turn into endless nights, and each brother vows to make her his own, Yui falls deeper and deeper into madness and ecstasy.

Maria is a powerful young witch living with her two familiars in medieval France during the Hundred Years' War against England. As the war rages on and the innocent get caught in its destruction, Maria becomes fed up with the situation and begins using her magic to try and prevent further conflict in hopes of maintaining peace. However, her constant intervention soon attracts the attention of the heavens, and the archangel Michael is sent to keep her from meddling in human affairs. The divine being confronts Maria, and he forbids her from using her powers, issuing a decree that her magic will be taken if she loses her virginity. Though she is now labeled a heretic, Maria adamantly refuses to heed Michael's warning and continues to disrupt the war between the two nations. But as the Church begins plotting to take away the witch's power and put a stop to Maria's interference once and for all, her peacemaking may soon come to an end. [Written by MAL Rewrite]