In the five hundred years since Earth's environment was destroyed and the planet came to be known as Terra, humans have created a society in space that is entirely logical. Supercomputers control the government, babies are grown in artificial wombs and assigned parents randomly, and at age 14, children take an "Adulthood Exam." Humanity's greatest enemy is the "Mu"—humans who have developed into espers. When Jomy Marquis Shin's birthday arrives and the time comes for him to take his Adulthood Exam, he is shocked to learn that all of his childhood memories are going to be erased. Suddenly, he hears the voice of Soldier Blue, the leader of the Mu, calling out to him to hold onto his memories. Jomy makes his escape on a Mu ship and is shocked to learn that he himself is an esper and that the government has sentenced him to death. Nearing the end of his life, Soldier Blue transfers his memories to Jomy and names him the next leader of the Mu. Now, Jomy has a choice: keep the Mu in hiding, or declare war on humanity to realize their dream of returning to Terra.

The anime follows a group of friends Giulia, Maria, Enrico, Lucio and Angelon during the disaster as they team up with a Japanese journalist Shiro Ando, and begin their own investigation of what's occurring (during the week long period of exposure when the ICMESA refused to notify citizens of the poison). As many animals are dying and people are getting sick. The children and Shiro discover deadly dioxin was released and inform Enrico's father, the town mayor, who evacuates all the citizens. Shiro continues investigating more and learns of the negligence of La Roche, a company who controls ICMESA. La Roche knew they were in violating of existing safety laws/protocols and destroyed evidence of their crimes. The children attend a press conference to ruin La Roche's reputation as the destroyed proof might not be enough in a court of law to punish them. Giulia's pregnant sister, who opted to not abort, gave birth to a healthy girl. The happiness is short lived, as the baby prematurely dies from dioxin poisoning.

August 1945. In a converted theological seminary on the outskirts of Nagasaki, a young doctor works to help his patients, as unsettling news comes of a new weapon used by the Americans on the city of Hiroshima. When the second nuclear weapon is dropped on Nagasaki, the hospital staff must work to save lives in the midst of the concentric circles of death that their city has become.

Based on the literary work of Shikibu Murasaki, The Tale of Genji is a story of the Emperor`s second son born by a courtier. Made a commoner, he served as a retainer to the court.