From her hometown to her daily life on Kurken Island, everything surrounding Reisalin "Ryza" Stout is painfully ordinary. Despite being the daughter of a hardworking farmer, she would rather go on pretend adventures as she explores almost every corner of the island. However, the fact that it is against the local customs to venture off Kurken Island irritates her to no end. One day, wishing for something interesting to finally happen in her life, Ryza escapes on a boat with her two good friends: the bookworm Tao Mongarten and the aspiring warrior Lent Marslink. Arriving at a nearby forest, the trio stumbles into Klaudia Valentz, the daughter of a visiting merchant who also wandered off into the woods. As the naive and underprepared group ventures further, they run into dangerous monsters. Thankfully, they are rescued by the alchemist Empel Vollmer and his skilled bodyguard Lila Decyrus. This fateful encounter will lead Ryza to the key that will change her life forever—the creative and wonderful world of alchemy.

"To be quiet and do as you're told, that's the cowardly choice." These are the words of Junk Dog, an underground fighter of Megalo Box, an evolution of boxing that utilizes mechanical limbs known as Gear to enhance the speed and power of its users. Despite the young man's brimming potential as a boxer, the illegal nature of his participation forces him to make a living off of throwing matches as dictated by his boss Gansaku Nanbu. However, this all changes when the Megalo Box champion Yuuri enters his shabby ring under the guise of just another challenger. Taken out in a single round, Junk Dog is left with a challenge: "If you're serious about fighting me again, then fight your way up to me and my ring." Filled with overwhelming excitement and backed by the criminal syndicate responsible for his thrown matches, Junk Dog enters Megalonia: a world-spanning tournament that will decide the strongest Megalo Boxer of them all. Having no name of his own, he takes on the moniker of "Joe" as he begins his climb from the very bottom of the ranked list of fighters. With only three months left to qualify, Joe must face off against opponents the likes of which he has never fought in order to meet the challenge of his rival. [Written by MAL Rewrite]

The Yuzuki family, which consists of four brothers, lost their parents two years ago. Hayato, the eldest son, is a hard worker and the pillar of the family. Mikoto, the second son, is calm and collected, but he has a soft spot for his younger brother Minato, whom he adores and thinks is cute. Minato, the third son, is energetic and adores his brothers, but he is clumsy and awkward. Gakuto, the fourth son, is a studious and mature first-grader who is often referred to as a "wise man." The manga depicts the four brothers' daily lives as they navigate their family, school, and community.

While walking through the forest one day, a witch named Alyssa finds a bush glowing with a magical aura. She discovers a baby who, although not a witch, possesses magic that is too strong for that of a mere human. As such, Alyssa decides to raise the child as her own, naming her Viola. Sixteen years later, Viola is all grown up and now towers over her youthful mother, and her mature looks cause many to confuse their ages. Nevertheless, Alyssa adores her child despite Viola's possessive streak and tendency to drive away anyone she fears will take away her mother's love. Viola may not be sure where she came from, though she has all she needs in Alyssa and the plethora of Alyssa's friends who have come together to raise her. Under Alyssa's guidance, Viola will learn to master her magic and make her adoptive mother proud.