In the world of Mushrambo, human life has all but come to an end. After a deadly virus threatened the extinction of mankind, a new race called the Enterrans was created to preserve life on Earth. However, relations between the Enterrans and their creators did not remain peaceful. Soon a war broke out with the Enterrans fighting against the humans and their robots. Ultimately the Enterrans were the victors of this conflict, renaming Earth as Enterra in honor of their victory. Before the last vestiges of humanity fell, one of the few remaining scientists put his daughter, Yakumo Shindou, into a sleep chamber. His hope was that his daughter would one day reawaken and find the human sanctuary known as Shinzo, reviving humanity and restoring peace between humans and Enterrans. Centuries have passed since the war; Yakumo now awakens and meets an Enterran named Mashura who pledges to assist in her quest. Also joined by the Enterrans Sago and Kutal, the group must now work to locate Yakumo's missing memories and locate Shinzo. But not every Enterran is as kind as Yakumo's new friends and some are prepared to commit any atrocity to prevent the return of humanity.

Hiyori Hayama is an aspiring singer who moved to Tokyo to make her debut. She has always loved singing and hopes to stand on stage like her favorite artist. Unfortunately, the entertainment industry is not all fun and games, as she fails her auditions one after another and struggles to sell her songs. Finding herself still standing at the start line, Hiyori pursues her only opportunity to take the next step forward—partaking in Extreme Hearts. The popular event is a Hyper Sports tournament where participants compete in various sports using ability-enhancing gear for a chance to make their big break. Despite being athletic, however, Hiyori's lack of familiarity with Hyper Sports poses a problem for her. Fortunately, she befriends girls experienced in different sports, and they join the tournament alongside Hiyori, hoping to see her rise to the top. Now playing under Team RISE, Hiyori and her teammates learn about the unspoken rule of Extreme Hearts—all competitors must be entertainers or aspire to be one. For the members of Team RISE, facing the competition head-on is an inspiring endeavor that paves the way to discovering newfound interests and everlasting friendships.

Five girls came to a training school to become voice actresses holding each thought in her mind. Momoko - she wanted to be a voice actress to meet her favorite voice actor. Rinka - she is an armature voice actress, but she didn't have special purpose to become voice actress. Yurika - she likes anime very much. Tsubasa - she was a girl in love, and acted only as a boy. Amane - she found a deadlock as a actress and tried to find another way. They managed to get over the difficulty to become voice actress although they couldn't perform as main characters yet. There is a love romance with a boy works for an anime company, and you can catch a glimpse of situations of anime industries.

Harry is definitely not your average American teenager. Instead, he is the epitome of an "alienated youth"—friendless at school, extremely weird, and nervous to the point of paranoia. But a chance occurrence causes Harry to start to demonstrate what appear to be psychic powers—yet he neither believes in them nor consciously controls them. However, there are other ominous forces at work who do believe in Harry and attempt to make use of him in ways that are threatening and frightful. (Source: AniDB, edited)