Anime based upon the original Argentine graphic novel series of the same name. The story follows the titular character who is a genetically engineered super-soldier; one of the creations of Dr. Von Reichter's diabolic experiments. (The fictional) Von Reichter is actually a former Nazi who conducted horrendous experiments during the second world war. He flees to South America where he continues his experiments which culminate in the creation of the "Cybers," one of which happens to be Cybersix. However, since the Cybers exhibit free will at an young age (an undesired trait), Von Reichter destroys all the Cybers to prevent a rebellion. In the present day, Cybersix is one of the Cybers who managed to escape and is living a quiet life under the alias of "Adrian Seidelman"; however, she finds out that her survival is dependent on a special substance that Von Reichter created and thus she is forced to hunt down the "Technos," a newer generation of super-soldiers created by him, in order to survive. Unintentionally, in the process, Cybersix becomes a superhero protecting the world from Dr. Von Reichter's creations and his evil plans.

The 1920s was a decade of great change and upheaval, with monstrous demons appearing across America. To combat this menace, the holy organization known as the Order of Magdalene was established. The organization's New York branch is home to the young and reckless Sister Rosette Christopher, as well as her partner Chrno. Tasked with the extermination of demonic threats, the renowned team is excellent at their job, despite causing extensive collateral damage on their missions. However, both Rosette and Chrno are driven by their dark pasts. Through exterminating demons, Rosette hopes to find her lost brother Joshua who was taken by the sinner and demon, Aion, with whom Chrno also shares a bloody history. The two of them must fight off the increasingly dangerous demonic menace and discover its source, while continuing to search for the truth behind Joshua's disappearance. [Written by MAL Rewrite]

Yukino and Kanade Sakurai are twin sisters that live together in a high school dorm. Although they are twins, they tend to act romantic toward each other, holding hands and going on dates. One day, Kanade sees Yukino hanging out with a new girl, Sakuya Kamiyama. Realizing how much time these two spend together, Kanade assumes they are dating, and she begins to distance herself from her sister. Yukino promptly notices and pleads with Kanade not to leave. In reality, Sakuya has only been asking for advice about Kanade, revealing her obsessive love. How will this love triangle play out? [Written by MAL Rewrite]

Megumi-chan is a girl with a secret past. She used to be a boy until she met a person she thought was a magic user. This person gave him/her a magical book from which a genie appears to grant one wish when blood is applied to it. Megumi made the wish to be a man in a man's body but the genie has a twist: he grants wishes backwards so he turns Megumi-kun aged 9 to Megumi-chan. Years pass and Megumi enters High School where she immediately beats up the school bully who of course falls in love with her. She is looking for that book again to be able to reverse the spell placed upon her. (Source: ANN)