Futari wa Precure protagonists Nagisa Misumi and Honoka Yukishiro are about as different as two people can get. Nagisa is the captain of the lacrosse team, a lover of food, and a hater of homework. Honoka loves to learn, working with the science club and earning the nickname "The Queen of Knowledge" from her fellow classmates. Their lives are unconnected until one day, when a mysterious star shower unites them. Nagisa and Honoka meet Mipple and Mepple, two residents of the Garden of Light. Their homeland has been conquered by the evil forces of the Dark Zone who now have their sights set on the Garden of Rainbows: Earth. With powers from the Garden of Light, Nagisa becomes Cure Black and Honoka becomes Cure White. Together, they are Pretty Cure! Now Pretty Cure must locate the Prism Stones, the only power strong enough to defeat the Dark Zone and repair the damage done to the Garden of Light. Will these magical girls be able to protect their home from the evil that threatens it? Or will they be sucked into the darkness?

Shortly after the fall of the Wicked King, the Queen of the Garden of Light lost her memory and came to Earth, in the form of a 12-year-old girl named Hikari Kujou. Now, she—with the help of Nagisa and Honoka, endowed with new costumes and powers—must find the 12 Heartiels, which hold the key to restoring the Queen's lost memories. For together once again, they are Pretty Cure. (Source: AniDB)

In the continent of Astraea, a man falls from the sky, possessing no memories other than his name, Yuuki. An elf named Kokkoro finds him, introducing herself as his guide in the world they are about to traverse. With Kokkoro's guidance, Yuuki is able to learn how this world works, from battling monsters to handling currency. To earn money for their journey, Yuuki and Kokkoro decide to go to a nearby guild association to accept a simple quest. In their expedition, they meet Pecorine, a somewhat gluttonous but charming girl skilled in battle. The next day, they also meet Karyl, a cat girl specializing in magic. After some time, a bond of friendship and camaraderie forms between them, and the four decide to create a guild of their own. As they continue their adventures, they explore the world, meet new people, and will perhaps uncover the mysteries behind Yuuki's missing memories. [Written by MAL Rewrite]

The story revolves around a girl named Yuuka, who encounters a being from the depths of the Earth named Chii-chan (a pun of chiteijin, the Japanese word for underground-dweller), and an alien named Ucchan (a pun of uchuujin or alien). The story follows their heartwarming and chaotic everyday lives together.