An innocent young man, Ikuroo, has a parasite known as Baoh implanted in his brain by an evil organization, Doress. The parasite makes him nearly immortal and gives him the ability to transform into a really powerful beastie when he's in trouble. Doress intends to use him in some sort of ploy for financial success, world domination, or something along those lines, but when they're transporting him on a train, a young psychic girl, Sumire (who's being held by the organization due to her abilities), sets him free and the two escape together. Of course, Dr. Kasuminome is the mad scientist behind the whole Baoh thing, and he isn't about to let his test subject get away and he has considerable resources (including some superpowered lackeys, as well as a small army) at his disposal.

A criminal group known as Demon Seed terrorizes Tokyo with its vast armies of mecha. The local police is afraid to confront them, but one person stands in their way: Maron Namikaze, a 13-year-old idol singer with a catchy voice and unbelievable superhuman strength.

After fainting at work, a young lady awakens in the back room of the café she works at with no memory of her life or those around her. Two of her friends, whom she soon learns are named Shin and Toma, are called to help her get home safely. Once she is alone, she meets a spectral boy named Orion that only she can see and hear. He explains that she lost her memories because of his chance visit to her world, so he vows to help her remember who she is. However, regaining her departed memories without worrying those around her may be more difficult than she realizes. In addition to the gloomy Shin and the protective Toma, she must be wary of arousing the suspicions of the captivating Ikki, the quick-witted Kent, and a mysterious man who lurks in the distance. As her amnesia entangles her in the lives of each of these men, her fragmented memories return piece by piece, and the mysteries of her circumstances slowly come to light. [Written by MAL Rewrite]

Super Sonico is a clutzy, adorable, and well-endowed 18-year old girl. She's a complete sucker for anything cute, especially stray cats, all of which she giddily adopts. However, though Sonico should be enjoying a carefree and simple lifestyle as a young college student, her life is really anything but easy: she must balance being a professional model, working part-time at her grandmother's restaurant, and practicing guitar and performing concerts with her friends Suzu Fujimi and Fuuri Watanuki in their band, First Astronomical Velocity—all while attending college. SoniAni: Super Sonico the Animation follows Sonico as she faces daunting challenges in her search for her place in the world, even when her days are brimming with love and happiness.