As Eishin Kuga—nicknamed "Mad Dog" for his unmistakable bloodlust—beats up his underlings, Yashiro watches and waits for his longtime friend to subdue him. Kanji Kageyama, an underground doctor, at last meets the young hothead whom Yashiro wants to recruit for his yakuza group. However, in light of Kuga's aversion toward Yashiro, Kageyama is ultimately left with the chore of temporarily housing him. But as Kageyama continues to insist that he has no interest in men, Kuga's shirtless presence, riotous attitude, and ceaseless teasing might just change his mind.

On a rainy afternoon, a male high school student awakens freezing on the streets with no memory of how he got there. His classmate and crush, Karen Inukai, finds him and takes him back to her home where, to his surprise, she starts to undress. She seems intent on bathing with him, though he has no idea why. When she holds him once more, he catches a glimpse of himself in the mirror—discovering that he has turned into a dog! Inukai adopts the puppy and names him Pochita. Now, he must adjust to life as a dog and figure out how to get out of this strange predicament. But while he mulls over an escape plan, Pochita sees a whole new side to Inukai that he never saw at school.

After warping light-years away from Earth, the spacecraft Macross carries a city of civilians and soldiers back home. They continuously fight off the threat of the Zentradi and Meltrandi, giant alien races with whom humanity wages war. During a battle, the Macross transforms into a mecha operated by fighter pilot Hikaru Ichijou. Thrust into a number of hardships, Hikaru grows close to the city's idol Minmay Lynn. As their relationship develops, however, it is viewed unfavorably by others due to Minmay's status and popularity. With war raging on and the state of Earth unknown, Hikaru and his fellow soldiers fight on against their mysterious enemies. Throughout the bloodshed, Hikaru and Minmay attempt to keep hold of their feelings for one another. Minmay pours her heart into her music, which may just turn out to be the key to finding peace.

Mitsuha Yamano could not have had it worse. After failing to enter her university of choice and losing her entire family in an accident, she finds herself plummeting off a cliff due to an especially fragile guardrail. Through what seems to be the only bit of the fortune left in her life, Mitsuha's firm unwillingness to die allows her to be transported to another world, where she ends up surviving. In this foreign land, Mitsuha wanders around for days before collapsing from exhaustion and being rescued by a little girl named Colette. Not long after, she finds herself in yet another life-threatening situation, and her indomitable will shines once more, granting her an audience with a divine cosmic being. The entity reveals to Mitsuha that she has acquired not only superhuman regeneration but also the ability to transport between worlds at will. Armed with this new information, Mitsuha brainstorms ways to utilize her newfound power to its full potential. Realizing that she can take goods from Earth and resell them to the other world at a higher price, she resolves to save up eighty thousand gold coins to be able to retire comfortably.