Ever since the fall of the DARK organization, Jiro has been wandering everywhere and wondering if he would ever see Mitsuko again or not. During his journey Jiro meets a beautiful girl named Rieko who is protecting Akira, a little boy from the evil Professor Gill. Ironicly, he's the son of Professor Gill, but he is also the key to Gill’s menacing secret weapon and his plans to conquer the world. (Source: ANN)

The genius robotics professor, Dr. Komyoji has created Jiro (who has the ability to transform into Kikaider) – a humanoid robot tasked with the protection of Dr. Komyoji’s son, Masaru, and daughter, Mitsuko. Gifted with a conscience circuit, which has the power to simulate real emotions that helps to distinguish between “right and wrong”, Jiro must protect Mitsuko and Masaru from the evil Dr. Gil who wants Jiro to join his army and aid in his goal of world domination. (Source: ANN)

Satoshi, Iris & Dent continue their travels through the Isshu region. After successfully winning his 8th Gym Badge against Homika in Tachiwaki City, Shirona invites everyone to stay at her villa in East Isshu, where old friend Hikari is also staying, and participate in the Pokemon World Tournament Junior Cup before Satoshi participates in the Unova League. Team Rocket, meanwhile, initiate their final plan for the Isshu region-what is their purpose in their desire for the legendary Pokémon Meloetta?

As with both the Advanced Generation and Diamond & Pearl series before it, the Best Wishes! series begins with only Satoshi, headed off to the Isshu region, located far away from Kanto, Johto, Houen, and Sinnoh, with his Pikachu. After he meets up with the new trainer and rival Shooty and the region's Professor Araragi, he gains traveling companions in Iris, a girl from a town known for its Dragon Pokémon, and Dent, Pokémon Connoisseur and the Grass Pokémon specialist of the three Sanyou City Gym Leaders.